Our Publications

Publications in 2023:

Papers:

  • Ghanbariamin, M. Samandari, P. Ghelich, S. Shahbazmohamadi, T. A. Schmidt, Y. Chen, A. Tamayol. Cleanroom-free fabrication of microneedles for multimodal drug delivery. Small. 2023 Jul;19(29):e2207131. doi: 10.1002/smll.202207131. PMID: 37026428 (IF: 13.3)
  • Yau, Z. Wang, N. Ponthempilly, Y. Zhang, X. Wang, Y. Chen. Biosensor Integrated Tissue Chips and Their Applications on Earth and in Space. Biosensors & Bioelectronics. 2023 Feb 15;222:114820. doi: 10.1016/j.bios.2022.114820. PMID: 36527831 (IF: 12.545)
  • Sapowadia, D. Ghanbariamin, L. Zhou, Q. Zhou, T. Schmidt, A. Tamayol, Y. Chen. Biomaterial Drug Delivery Systems for Prominent Ocular Diseases. Pharmaceutics 2023, 15(7), 1959; https://doi.org/10.3390/pharmaceutics15071959
  • Yau, A. Jogdand, Y. Chen. Blood-brain-barrier modeling with tissue chips for research applications in space and on Earth. Frontiers in Space Technologies, Volume 4, 2023; https://doi.org/10.3389/frspt.2023.1176943
  • Nagri, O. Rice, Y. Chen. Nanomedicine strategies for central nervous system (CNS) diseases. Frontiers in Biomaterials Science, Volume 2, 2023; https://doi.org/10.3389/fbiom.2023.1215384
  • Nikhil G. Menon, Adam P. Tanguay, Libo Zhou, Ling X. Zhang, Cedric E. Bobst, Mingyu Han, Mallika Ghosh, George W. Greene, Alix Deymier, Benjamin D. Sullivan, Yupeng Chen, Gregory D. Jay, Tannin A. Schmidt. A structural and functional comparison between two recombinant human lubricin proteins: Recombinant human proteoglycan-4 (rhPRG4) vs ECF843. Experimental Eye Research, Volume 235, October 2023, 109643; https://doi.org/10.1016/j.exer.2023.109643
  • Wuxia Zhang, Yupeng Chen. Recently Published Patents on Janus Base Nanomaterials for RNA Delivery. Current Organic Chemistry, 2023, 27, 1738-1740. DOI: 10.2174/0113852728266064231017181717
  • Wuxia Zhang, Yupeng Chen. Self-assembled Janus base nanotubes: chemistry and applications. Frontiers in Chemistry, Volume 11, 2023; https://doi.org/10.3389/fchem.2023.1346014
  • Leah Faber, Anne Yau, Yupeng Chen. Translational biomaterials of four-dimensional bioprinting for tissue regeneration. Biofabrication, Volume 16, Number 1, 2023. DOI 10.1088/1758-5090/acfdd0 (IF: 11.061)

Conference proceedings and presentations:

  • Yau, I. Sands, J. Lee, Y. Chen. Development Of Engineered Cartilage Tissue Construct Maintaining Healthy Function Of Cartilage Cells. Trans Orthop Res Soc., 2023; 48:0614.
  • Delaram Ghanbariamin, Mohamadmahdi Samandari, Yupeng Chen, Ali Tamayol. Facile and Cleanroom-Free Fabrication of Hollow Microneedles Supporting Multimodal Drug Delivery. BMES Annual Meeting, 2022.
  • Maxwell Landolina, Anne Yau, Yupeng Chen. Response Surface Analysis of Janus Base Nano-Matrix Components for Growth Plate Repair. BMES Annual Meeting, 2022.
  • NG Menon, AP Tanguay, L Zhou, LX Zhang, CE Bobst, G Greene, A Deymier, BD Sullivan, Y Chen, GD Jay, TA Schmidt. Biophysical and Functional Characterization of Recombinant Human Lubricin Proteins: rhPRG4 vs ECF843. The association for research in vision and ophthalmology (ARVO) annual meeting, 2023.
  • Anne Yau, Ian Sands, Jinhyung Lee, Yupeng Chen. Development of Engineered Cartilage Tissue Construct Maintaining Healthy Function of Cartilage Cells. Orthopaedic Research Society annual meeting, 2023.
  • Jinhyung Lee, Wuxia Zhang, Jin Zhai, Trystin Cote, Yupeng Chen. DNA-inspired Nanopieces for mRNA Delivery. 9th SOE/SAGE Poster Competition, 2023.
  • Jinhyung Lee, Jin Zhai, Wuxia Zhang, Trystin Cote, Yupeng Chen. Janus Base Nanopieces for mRNA Delivery. 5th Annual RNA Therapeutics Conference, 2023.
  • Ian Sands, Alpaslan Ersoz, Wuxia Zhang, Libo Zhou, Will Linthicum, Sabato Santaniello, Bryan Huey, Martin Han, Yupeng Chen. DNA-Inspired Electrically Conductive Nanocoating for Intracortical Microelectrode Stimulation and Recording. Society For Biomaterials Annual meeting, 2023.
  • Yupeng Chen, Anne Yau, Maxwell Landolina, Mari Anne Snow. In-Space Fabrication of Bio-Inspired Janus Base Nanomaterials. The annual International Space Station Research and Development Conference, 2023.
  • Jinhyung Lee, Yupeng Chen. DNA-Inspired Nanomaterials for Small-Molecule Delivery to “Hard-to-Penetrate” Solid Tumors. Keystone Symposia: Next-Generation Nanomedicine, 2023.
  • Jin Zhai, Jinhyung Lee, Wuxia Zhang, Yupeng Chen. Long-Term and Room-Temperature Stability of DNA-Inspired Janus-Based Nanopieces for Large mRNA Delivery. BMES Annual Meeting, 2023.
  • Maxwell Landolina, Anne Yau, Yupeng Chen. In-Space Fabrication and Computation-Aided Optimization of Janus Base Nano-Matrix for Cartilage Regeneration. BMES Annual Meeting, 2023.
  • Jinhyung Lee, Wuxia Zhang, Jin Zhai, Trystin Cote, Ian Sands, Yupeng Chen. DNA-inspired Janus Base Nanopieces for In Vivo Gene Editing in Liver. BMES Annual Meeting, 2023.
  • Jinhyung Lee, Wuxia Zhang, Jin Zhai, Trystin Cote, Elham Ahmadi, Kepeng Wang, Ying Li, Yupeng Chen. Computation-aided Design of DNA-inspired Janus Base Nanomaterials for Small Molecules Delivery. BMES Annual Meeting, 2023.

     

    Publications in 2022:

    Papers:

    • Li, J. Yang, G. Wu, Z. Weng, Y. Song, Y. Zhang, J. A. Vanegas, L. Avery, Z. Gao, H. Sun, Y. Chen, K. D. Dieckhaus, X. Gao, Y. Zhang. Amplification-Free Detection of SARS-CoV-2 and Respiratory Syncytial Virus Using CRISPR Cas13a and Graphene Field-Effect Transistors. Angewandte Chemie. 2022, May 12; https://doi.org/10.1002/anie.202203826 PMID: 35559592 (Impact Factor: 16.823)
    • Rice, O., Surian, A., & Chen, Y. (2022). Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases. Journal of Tissue Engineering, 13, 20417314221095997.
    • Landolina, M., Yau, A., Chen, Y. Fabrication and Characterization of Layer-by-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration. J. Vis. Exp. (185), e63984, doi:10.3791/63984 (2022).
    • S. Griger, I. Sands, Y. Chen. Comparison between Janus-Base Nanotubes and Carbon Nanotubes: A Review on Synthesis, Physicochemical Properties, and Applications. International Journal of Molecular Sciences. 2022, 23(5), 2640; https://doi.org/10.3390/ijms23052640 PMID: 35269782

    Conference proceedings and presentations:

    • Anne Yau, Libo Zhou, Wuxia Zhang, Yupeng Chen. A Library of Janus Base Nano-Matrices for Tissue Engineering. Orthopaedic Research Society annual meeting, 2022.
    • TA Schmidt, N Menon, A Tanguay, L Zhou, Han M, Whitehead RD III, Teschke CM, Greene GW, Deymier A, Y Chen, GD Jay, BD Sullivan. Biophysical characterization of recombinant human Proteoglycan 4 (rhPRG4): Effect of Mg2+ and high pH. The Association for Research in Vision and Ophthalmology Annual Meeting, 2022.
    • Ian Sands, Wuxia Zhang, Will Linthicum, Bryan Huey, Yupeng Chen. DNA-Inspired Nanotubes for Enhanced Neural Cell Interfacing. 8th SOE/SAGE Poster Competition, 2022.
    • Anne Yau, Wuxia Zhang, Yupeng Chen. Injectable Self-Assembled Janus-base Nano-Matrix for Cartilage-on-a-Chip. 8th SOE/SAGE Poster Competition, 2022.
    • Ian Sands, Martin Niemic, Nathaniel Keri, Wuxia Zhang, Libo Zhou, Will Linthicum, Bryan Huey, Martin Han, Yupeng Chen. Biomimetic Electrically Conductive Coating for Enhanced Brain Microelectrode Interface. Northeast Bioengineering Conference, 2022.
    • Anne Yau, Ian Sands, Yupeng Chen. Development of Injectable Janus Base Nano-matrix for Cartilage Tissue Chip Applications. The annual International Space Station Research and Development Conference, 2022.
    • Yau, L. Zhou, W. Zhang, Y. Chen. A Library of Janus Base Nano-Matrices for Tissue Engineering. Trans Orthop Res Soc., 2022; 47:0417.
    • Leah Faber, Anne Yau, Ryan Stack, Yupeng Chen. Bioprinting using Chondrogenic Janus Base Nano-Matrix for Improved Cartilage Tissue Engineering. BMES Annual Meeting, 2022.
    • Jinhyung Lee, Wuxia Zhang, Jin Zhai, Trystin Cote, Yupeng Chen. DNA-inspired Nanopieces for mRNA Delivery. BMES Annual Meeting, 2022.
    • Anne Yau, Wuxia Zhang, Yupeng Chen. Injectable Janus Base Nano-Matrix for Cartilage Tissue Chips. BMES Annual Meeting, 2022.
    • Delaram Ghanbariamin, Mohamadmahdi Samandari, Yupeng Chen, Ali Tamayol. Facile and Cleanroom-Free Fabrication of Hollow Microneedles Supporting Multimodal Drug Delivery. BMES Annual Meeting, 2022.
    • Maxwell Landolina, Anne Yau, Yupeng Chen. Response Surface Analysis of Janus Base Nano-Matrix Components for Growth Plate Repair. BMES Annual Meeting, 2022.

     

    Publications in 2021:

    Books:

    • Musculoskeletal Tissue Engineering, 1st Edition. Yupeng Chen (Editor). Elsevier (Publisher). November 4, 2021. Paperback ISBN: 9780128238936. eBook ISBN: 9780128242100.

    Papers:

    • J. Lee, I. Sands, W. Zhang, L. Zhou, Y. Chen. DNA-inspired nanomaterials for enhanced endosomal escape. Proc Natl Acad Sci USA. May 11, 2021 118 (19) e2104511118. DOI: https://doi.org/10.1073/pnas.2104511118 (Impact Factor: 12.779)
    • L. Zhou, W. Zhang, J. Lee, L. Kuhn, Y. Chen. Controlled Self-Assembly of DNA-Mimicking Nanotubes to Form a Layer-by-Layer Scaffold for Homeostatic Tissue Constructs. ACS Applied Materials & Interfaces. 2021 Nov 3;13(43):51321-51332. doi: 10.1021/acsami.1c13345. PMID: 34663065 (Featured as the cover image.) (Impact Factor: 10.383)
    • A. Yau, J. Lee, Y. Chen. Nanomaterials for Protein Delivery in Anticancer Applications. Pharmaceutics 2021, 13, 155. DOI: https://doi.org/10.3390/pharmaceutics13020155. PMID: 33503889

        Book chapters:

        • Zhou, A. Sapowadia and Y. Chen. Cartilage Tissue Engineering. Yupeng Chen (Ed.), Musculoskeletal Tissue Engineering 1st Edition, November 4, 2021, pp41-66. Paperback ISBN: 9780128238936. eBook ISBN: 9780128242100.
        • Yau, K. Yeh and Y. Chen. Musculoskeletal Tissue Chips. Yupeng Chen (Ed.), Musculoskeletal Tissue Engineering 1st Edition, November 4, 2021, pp275-304. Paperback ISBN: 9780128238936. eBook ISBN: 9780128242100.
        • W. Zhang, E. Kilian and Y. Chen. Drug and Gene Delivery for Musculoskeletal Tissues. Yupeng Chen (Ed.), Musculoskeletal Tissue Engineering 1st Edition, November 4, 2021, pp305-318. Paperback ISBN: 9780128238936. eBook ISBN: 9780128242100.

        Conference proceedings and presentations:

        • L. Zhou, J. Lee, W. Zhang, Y. Chen. A bionic layer-by-layer drug-released Nano-Matrix for mesenchymal stem cells chondrogenic differentiation promotion and chondrocytes hypertrophy prevention. Trans Orthop Res Soc., 2021;46:0350.
        • Jinhyung Lee, Ian Sands, Wuxia Zhang, Libo Zhou, Yupeng Chen. DNA-inspired Nanopiece for efficient siRNA delivery in anti-virus application. UConn 7th SOE/SAGE Poster Competition, 2021.
        • Anne Yau, Wuxia Zhang, Yupeng Chen. Injectable Self-Assembled Nano-Matrix for Cartilage-on-a-Chip. UConn 7th SOE/SAGE Poster Competition, 2021.
        • Samira Hajebrahimi, Soliman Alhudaithy, Jinhyung Lee, Yupeng Chen, Kazunori Hoshino. Effect of Drug Treatment on Tumor Stiffness. UConn 7th SOE/SAGE Poster Competition, 2021.
        • Libo Zhou, Jinhyung Lee, Wuxia Zhang, Yupeng Chen. A bionic layer-by-layer drug-released Nano-Matrix for mesenchymal stem cells chondrogenic differentiation promotion and chondrocytes hypertrophy prevention. Orthopaedic Research Society annual meeting, 2021.
        • Jinhyung Lee, Ian Sands, Wuxia Zhang, Libo Zhou, Yupeng Chen. DNA-inspired nanomaterials for intracellular delivery of RNAi. ACS Annual Meeting, Fall 2021.
        • Ian Sands, Nathaniel Keri, Wuxia Zhang, Libo Zhou, Will Linthicum, Bryan Huey, Martin Han, Yupeng Chen. Electrically Conductive DNA-Inspired Coating for Brain Microelectrode Interface Enhancement. 4th CMU Forum on Biomedical Engineering, 2021.
        • Jinhyung Lee, Ian Sands, Wuxia Zhang, Libo Zhou, Yupeng Chen. DNA-inspired Nanopieces for RNA delivery and enhanced endosomal escape. BMES Annual Meeting, 2021.
        • Aaron Beams, Jinhyung Lee, Wuxia Zhang, Yupeng Chen. Intracellular Protein Delivery using Nanopieces for Anti-Cancer Applications. BMES Annual Meeting, 2021.
        • Allison Surian, Jinhyung Lee, Wuxia Zhang, Samira Hajebrahimi, Kazunori Hoshino, Yupeng Chen. Codelivery of Doxorubicin and siRNA via Janus Based Nanopiece for Improved Cancer Treatment. BMES Annual Meeting, 2021.
        • Anne Yau, Libo Zhou, Wuxia Zhang, Yupeng Chen. A Library Janus Base Nano-Matrices to Selectively Promote Different Cell Lineage Adhesion. BMES Annual Meeting, 2021.
        • Ian Sands, Nathaniel Keri, Libo Zhou, Wuxia Zhang, Martin Han, Yupeng Chen. Electrically Conductive DNA-Inspired Nano-Coating for Enhanced Neural Interfaces. BMES Annual Meeting, 2021.

           

          Publications in 2020:

          Papers:

          • M. Sun, J. Lee, Y. Chen and K. Hoshino. Studies of nanoparticle delivery with in vitro bio-engineered microtissues. Bioactive Materials 2020; 5(4); 924-937. DOI: https://doi.org/10.1016/j.bioactmat.2020.06.016 (Impact Factor: 16.874)
          • L. Zhou, A. Yau, H. Yu, L. Kuhn, W. Guo and Y. Chen. Self-assembled biomimetic Nano-Matrix for stem cell anchorage. J Biomed Mater Res A. 2020 Apr;108(4):984-991. doi: 10.1002/jbm.a.36875. Epub 2020 Jan 10. PMID: 31904174
          • I. Sands, J. Lee, W. Zhang and Y. Chen. RNA Delivery via DNA-Inspired Janus Base Nanotubes for Extracellular Matrix Penetration. MRS Advances. Epub 2020 Jan 24. DOI: https://doi.org/10.1557/adv.2020.47
          • L. Zhou, L. E. Rubin, C. Liu and Y. Chen. Short Interfering RNA (siRNA)-Based Therapeutics for Cartilage Diseases. Regenerative Engineering and Translational Medicine. Epub 2020 Jan 29. DOI: 10.1007/s40883-020-00149-z
          • L. Zhou, A. Yau, W. Zhang and Y. Chen. Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion. J. Vis. Exp. (159), e61317, doi:10.3791/61317 (2020).

            Conference proceedings:

            • L. Zhou, A. Yau, H. Yu, L. Kuhn, W. Guo, Y. Chen. Improving Mesenchymal Stem Cell Homing by Self-Assembled Fibronectin/Janus-Base Nanotube Matrix. Trans Orthop Res Soc., 2020;45:1426.
            • W. Zhang, Z. Shen, H. Yu, Y. Li, Y. Chen. Anti-Cancer Drug Delivery via DNA-Inspired Janus Base Nanotubes. Trans Orthop Res Soc., 2020;45:2222.
            • Y. Chen. RNAi therapy using Janus base nanotubes against cartilage degradation. American Institute of Chemical Engineers annual meeting. 2020: 616640.

            Conference presentations:

            • Novel bio-scaffolds Janus Base Nano-Matrix for Mesenchymal Stem Cell homing. Orthopaedic Research Society annual meeting, 2020.
            • Anti-Cancer Drug Delivery via DNA-Inspired Janus Base Nanotubes. Orthopaedic Research Society annual meeting, 2020.
            • Self-Assembled Biomimetic Nano-Matrix for Stem Cell Anchorage in Tissue Chip. UConn SOE Poster Competition, 2020.
            • DNA-inspired Nanopiece for enhanced endosomal escape and efficient RNA delivery. UConn SOE Poster Competition, 2020.
            • Electrochemical Characterization of Nanotube Coatings on Silicon-based microelectrodes. Connecticut Symposium on Microelectronics & Optoelectronics, 2020.
            • DNA-inspired JBNT Nanopiece for efficient and high biocompatible siRNA carrier. 3rd CMU Forum on Biomedical Engineering, 2020.
            • Injectable Janus Base Nano-Matrix for Improved Cell Functions in Tissue Chips. BMES Annual Meeting, 2020.
            • Electrically Conductive Janus Base Nano-Coating For Brain Machine Interface Enhancement. BMES Annual Meeting, 2020.
            • Self-assembled Janus Base Nanopieces for RNA Delivery and Endosomal Escape. BMES Annual Meeting, 2020.
            • Electrochemical Characterization of Nanotube Coating on Silicon-Based Microelectrodes. MRS Annual Meeting, F-FL02, 2020.

               

              Publications in 2019:

              Papers:

              • X. Sun, Y. Chen, H. Yu, J. T. Machan, A. Alladin, J. Ramirez, R. Taliano, J. Hart, Q. Chen, R. M. Terek. Anti-miRNA Oligonucleotide Therapy for Chondrosarcoma. Molecular Cancer Therapeutics. 2019 Jul 24. pii: molcanther.1020.2018. doi: 10.1158/1535-7163.MCT-18-1020.
              • A. Yau, H. Yu and Y. Chen. mRNA Detection with Fluorescence-base Imaging Techniques for Arthritis Diagnosis. Journal of Rheumatology Research. 2019; 1(2): 39-46.
              • A. Yau, I. Sands and Y. Chen. Nano-Scale Surface Modifications to Advance Current Treatment Options for Cervical Degenerative Disc Disease (CDDD). J Orthop Res Ther 2019; 4: 1147. DOI: 10.29011/2575-8241.001147
              • Y. Chen and W. Zhang. Molecular Engineering of DNA-Inspired Janus Base Nanomaterials. Juniper Online Journal Material Science 2019; 5(4); 1-3. DOI: 10.19080/JOJMS.2019.05.555670

              Book chapters:

              • X. Sun, A. Yau, Y. Chen. Biomedical applications and biomaterial delivery strategies of growth factors, Lei Yang, Sarit B. Bhaduri and Thomas J. Webster (Ed.). Woodhead Publishing, ISBN: 978-0-12-813477-1. 2019.
              • J. Lee and Y. Chen. Nucleic Acid Delivery Systems for Gene Therapy, Vanessa Zimmer (Editor), Gene Delivery: Methods and Applications. Nova Science Publisher, ISBN: 978-1-53616-268-4. 2019.

                Conference proceedings:

                • M. Terek, X. Sun, Y. Chen, H. Yu, J. Machan, J. Hart, Q. Chen. Janus Base Derived Nanopieces for Delivery of Anti-miRNA Oligonucleotides in Chondrosarcoma. Trans Orthop Res Soc., 2019;44:2191.
                • A. Yau, H. Yu, W. Guo, Y. Chen. Improving Mesenchymal Stem Cell Homing by Self-Assembled Fibronectin/Janus-Base Nanotube Matrix. Trans Orthop Res Soc., 2019;44:756.

                Conference presentations:

                • “Improving Mesenchymal Stem Cell Homing by Self-Assembled Fibronectin/Janus-Base Nanotube Matrix.” Orthopaedic Research Society annual meeting, 2019.
                • “Janus Base Derived Nanopieces for Delivery of Anti-miRNA Oligonucleotides in Chondrosarcoma.” Orthopaedic Research Society annual meeting, 2019.
                • “Self-assembled Janus Base Nano-Matrix Enhanced Mesenchymal Stem Cell Migration and Adhesion.” Biomedical Engineering Society annual meeting, 2019.
                • “DNA-Inspired Janus Base Nanotubes for Hydrophobic Drug Delivery.” Biomedical Engineering Society annual meeting, 2019.
                • “Biomimetic Nano-Matrix for Long-term Homeostasis in Cartilage Tissue Engineering”, SelectBio Space Summit Meeting, 2019.
                • “RNA delivery via DNA-inspired Janus Base Nanotubes for Extracellular Matrix Penetration”, MRS Annual Meeting, 2019.